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WHO recommendations for vaccine components for the 2022-23 northern hemisphere flu season

25 February, 2022

The World Health Organization (WHO) recommends the influenza strains to be included in each hemisphere's annual flu vaccination. They choose the virus strains most likely to cause widespread disease in the hemisphere's upcoming flu season, based on data collected in the months prior. Sometimes the formulations are the same for each hemisphere. The components recommended to be included in vaccines for the 2022-2023 northern hemisphere influenza season are the same as those recommended for the upcoming 2022 southern hemisphere flu season.

The composition varies depending on whether the vaccination is an egg-based type, or cell or recombinant type vaccines. The recommended strains are:

Egg-based vaccines

  • an A/Victoria/2570/2019 (H1N1)pdm09-like virus;
  • an A/Darwin/9/2021 (H3N2)-like virus;
  • a B/Austria/1359417/2021 (B/Victoria lineage)-like virus; and
  • for quadrivalent vaccines the fourth strain is a B/Phuket/3073/2013 (B/Yamagata lineage)-like virus.

Cell culture- or recombinant-based vaccines

  • an A/Wisconsin/588/2019 (H1N1)pdm09-like virus;
  • an A/Darwin/6/2021 (H3N2)-like virus;
  • a B/Austria/1359417/2021 (B/Victoria lineage)-like virus;
  • for quadrivalent vaccines the fourth strain is a B/Phuket/3073/2013 (B/Yamagata lineage)-like virus.

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