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In a preprint article published in medRxiv not yet certified by peer review, researchers assessed the diagnostic value of new skin rashes in SARS-CoV-2 infection. The study was conducted through an observational study, including data collected between 7 May and 22 June 2020, from the COVID Symptom Study app and from an independent online survey on skin-related symptoms. There were about 336,847 volunteer samples from the UK users of COVID Symptom Study app and more than 11,500 surveys from people aged 1 to 90 years old.
The results showed “In the app data, 8.8% of the swab positive cases (N=2,021) reported either a body rash or an acral rash, compared to 5.4% of those with a negative swab test (N=25,136) [...] Skin rashes were also predictive in the larger untested group of symptomatic app users (N=54,652), as 8.2% of those who had reported at least one classic COVID-19 symptom, i.e., fever, persistent cough, and/or anosmia, also reported a rash. Data from the independent online survey showed that in 17% of swab positive cases, the rash was the initial presentation. Furthermore, in 21%, the rash was the only clinical sign.”
The authors concluded, “Skin rashes cluster with other COVID-19 symptoms, are predictive of a positive swab test and occur in a significant number of cases, either alone or before other symptoms. Recognising rashes is important for the early detection of COVID-19 cases”
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