A study which reviewed crew of a fishing vessel from Seattle, in Washington State, USA, found that three people who had neutralizing antibodies to COVID-19 were not re-infected in an outbreak on board. The study took place in May, testing the crew prior to departure for infection (PCR test) as well as previous exposure (antibodies). None were positive on PCR up to 2 days prior to departure, 6 people had antibodies however only 3 of them had "neutralizing activity" against SARS-CoV-2. The ship returned 18 days later, after the outbreak occurred and one person required hospitalisation. Retesting showed that 104 of the 122 crew had been infected. The 3 people with neutralizing antibodies were not re-infected, however the other 3 tested positive for infection on PCR. The researchers conclude "neutralizing antibodies from prior infection was significantly associated with protection against re-infection". It is unclear how the outbreak started, since pre-departure testing showed no one with active infection. However it is possible that the 3 who were antibody positive but did not have neutralizing antibodies were "in the early stages of active infection". Genetic analysis of the virus showed the infections on board were all linked. The study has not yet been peer-reviewed.
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